the incidence of cancer is increasing. Several environmental and genetic factors predispose cancer patients. Majority of these factors result in upregulation of pro-survival pathways, downregulation of tumor suppressors and chronic inflammation. The ratio of w-6 (omega 6)/ w-3 (omega 3) polyunsaturated fatty acids (PUFAs) plays a very crucial role in cancer initiation and progression. A low w-6 / w-3 PUFA ratio has been shown to be beneficial in the management of cancer characteristics. Huge data from cancer cell lines and in vivo cancer models have provided insights into the mechanisms underlying the anticancer effects of w-3 PUFAs. Here, we discussed important potential mechanisms for beneficial effects of w-3 PUFAs as revealed by preclinical in vitro cancer cell line models and in vivo models. Non-oxidized omega 3 fatty acids are high in EPA and DHA. Most commercially produced fish oil is oxidized. For legal reasons, I am not allowed to name the brand of a good fish oil. In a personal conversation, of course, you may. References: Stephenson JA, Al-Taan O, Arshad A, Morgan B, Metcalfe MS, Dennison AR.
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