As is often the case and thus also with vitamins, a good balance is most important. Too little vitamin D can cause symptoms but so can too much. More and more you hear in the media that many people have vitamin D deficiency according to a measurement in the blood at the doctor's and that they have to supplement this deficiency.............. But supplementing this deficiency can have a downside in patients with chronic conditions. Professor Doctor Trevor Marshall suffered from the disease sarcoidosis. This is a condition in which inflammation occurs spontaneously all over the body. Often the lungs become the most affected. The disease can become chronic and in some cases even lead to death. No conventional treatment exists against this condition to date. Therefore, Marshall did her own research and delved into the studies of Doctor Lida Mattman, among others. She discovered that many chronic diseases may be caused by cell wall-less bacteria, the so-called L-form bacteria. However, cell wall-less bacteria are very difficult to detect. Thus, they cause symptoms without being able to identify the cause. Therefore, according to Mattman's study, it is possible that the following diseases are caused by cell-wall-less bacteria: sarcoidosis, arthritis, MS, fibromyalgia, CFS, Hashimoto-thryroiditis, Crohn's, lupus, Parkinson's, ALS, Lyme disease (Borrelia bacteria) and many more chronic conditions. In 2004, Marshall also demonstrated that cell wall-less bacteria may be the cause of several autoimmune diseases, and that some patients suffering from such a disease probably respond positively to antibiotics for this reason. There are some types of antibiotics that also combat cell wall-less bacteria, such as tetracyclines and macrolides, but their effect is usually not great enough to overcome the entire infection. Marshall, by necessity, therefore developed his own protocol. This protocol is based on the hypothesis that vitamin D, due to the presence of cell wall-less bacteria, is not properly converted. In fact, in a healthy body, vitamin D is converted into a small amount of 1,25 dihydroxyvitamin D (1,25 D). This is the active form of vitamin D. The kidneys regulate the amount of 1,25 D, because too much of it can be very harmful. 1,25 D attaches to the vitamin D receptor (VDR), from which a variety of important biochemical processes are controlled. Cell wall-less bacteria probably secrete substances that disrupt the action of the vitamin D receptor. For example, research has shown that in people with autoimmune disease, the following body processes occur:

  • The enzyme CYP27B1 is activated, converting vitamin D to l,25 D very quickly, causing the l,25 D level to rise and the vitamin D (25 OH) level to fall.
  • The production of the enzyme CYP24A1 is inhibited, so high 1,25 D levels are not regulated and thus remain high.
  • High 1,25 D levels prevent vitamin D production.

All these dysregulated processes lead to very high 1,25 D levels and low vitamin D levels. This is highly undesirable, as it completely disrupts the immune system. In addition, the combination also causes hormonal imbalance. An elevated 1.25 D level may therefore be an indication of an autoimmune disorder. Starting at 60 pmol/L, there would be an increased Th1 response, meaning the body is attacking itself. Strangely, vitamin D levels are almost always determined without looking at 1,25 D levels. Thus, it is necessary to have both tested, because additional supplementation of vitamin D is actually counterproductive in a situation where 1,25 D is elevated. This causes 1,25 D to rise further when it was already too high and therefore possibly causing symptoms.

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