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What are autoimmune diseases?
Autoimmune diseases are a class of conditions that occur when the body is attacked by its own immune system.
In normal situations, the immune system protects the body from bacteria and viruses that can cause disease. When it detects these invading agents, it produces proteins called antibodies to neutralize them.
But in some people, the immune system mistakes internal cells for foreign invaders and attacks them instead. Sometimes a single organ is targeted; in other situations, the entire body is affected.
Autoimmune diseases include conditions such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, lupus, pernicious anemia, celiac disease, psoriasis and many others. They range from well-known to extremely rare.
In type 1 diabetes, the immune system attacks the cells that produce insulin, the hormone that regulates blood sugar. As fewer cells produce insulin, the hormone is depleted and blood sugar levels rise. In lupus, the immune system attacks the entire body, damaging the kidneys, joints, brain and heart.
Why autoimmune diseases are a major concern
Autoimmune diseases are on the rise worldwide. In the United States, its prevalence has increased 50% over the past 25 years.
The exact cause of the abnormal immune responses that cause these diseases is still unknown. Exposure to certain chemicals, a Western diet and a family history with disease are often considered predisposing factors. One study even suggests that modern hygiene standards are the culprit; we are not as exposed to germs as we used to be, so the immune system over reacts to non-threatening factors while trying to stay active.
Treatment of autoimmune diseases currently focuses on moderating the body's immune response. Scientists continue to work on a treatment.
NAD+ and autoimmune disease
One substance in particular shows promise as a treatment for autoimmune diseases.
It is NAD+.
NAD - Nicotinamide Adenine Dinucleotide - is a biochemical compound found in all body cells. It is crucial for the health of cells and the body as a whole. This is because it helps maintain the process of energy production and transfer in each cell. This allows cells, tissues and entire organs to continue to function optimally.
Positive benefits of NAD+ IV therapy
In general, NAD+ keeps nerves healthy, maintains muscle mass and strength, protects the heart and slows aging. It protects against the effects of stress and is linked to immune system function against disease-causing viruses and bacteria.
NAD+ levels decrease with age. Reduced NAD+ levels have also been consistently observed in people with a wide range of conditions. Tests show that increasing NAD+ can help reverse the symptoms of these conditions.
Research shows that NAD+ could also be effective against autoimmune diseases. Available evidence suggests that NAD+ regulates immune responses and can turn destructive autoimmune cells into protective cells. It is studies like these that inspire the use of NAD+ as a treatment for autoimmune diseases.
The evidence for the success of NAD+ therapy in autoimmune diseases
Here we discuss the research that has been done on the efficacy of NAD+ treatment in some of the most common autoimmune diseases.
People with diabetes have lower amounts of NAD+ in their body tissues than normal. This has serious consequences for their health - they suffer more from oxidative stress, leading to the many complications we associate with the disease.
Experts suspected that increasing NAD+ levels in diabetics could reverse these complications. There is now increasing evidence for this: studies have demonstrated the effectiveness of NAD+ in patients when administered intravenously.
In multiple sclerosis, the immune system attacks the myelin sheath, a protective layer of nerve cells. As a result, signals transmitted between these cells become slower. This causes the symptoms associated with the disease: numbness, poor balance and difficulty walking.
Researchers have shown that NAD+ can restore balance to the immune system and reverse the damage of autoimmune reactions. Based on the results of such studies some experts have encouraged the development of NAD-based therapies for multiple sclerosis patients.
Inflammatory bowel disease
Inflammatory bowel syndrome is a class of diseases that affect the intestinal tract. Examples include Crohn's disease, which can occur in any part of the intestine, from the mouth to the anus; and ulcerative colitis, in which only the lining of the colon and rectum becomes inflamed.
Lower NAD+ leads to erosion of the protective mucus lining the intestinal walls and inflammation of intestinal cells. Experiments have shown that increasing NAD+ can reverse intestinal inflammation and improve the condition of intestinal walls.
Rheumatoid arthritis is an autoimmune disease that causes pain and damage to joints throughout the body. Existing treatments focus on treating the symptoms, but do not address the autoimmune problems that cause these symptoms.
NAD+ therapy offers another, more durable way to treat this disease. This study indicates that the NAD+ metabolism is an essential factor in the development of rheumatoid arthritis and suggests that increasing NAD levels may help fight the disease.
This autoimmune disease causes skin cells to rapidly accumulate in thick patches on the hands, feet, neck, scalp or face. These areas of skin are red and painful; sometimes they break and bleed.
Results of contemporary research say that nicotinamide, a component of NAD, could reduce cell division in Psoriasis, and ultimately improve the condition.
How is NAD+ administered?
Given the effectiveness of NAD+ IV Therapy for such a wide range of conditions, it is not surprising that it is now a much sought-after treatment. While there are a number of ways to administer it, not all are equally effective.
The body does not absorb all NAD+ administered orally (in the form of tablets). Some of it is lost during its journey through the digestive tract.
But when NAD+ is administered intravenously, the substance reaches every part of the body through the bloodstream. You can expect better results from this treatment than from oral intake.
The growing concern about the prevalence of autoimmune diseases is justified. So is the excitement about possible NAD+ IV therapy as a treatment for some of these diseases. Evidence for its efficacy continues to accumulate, even as research continues to shed more light on how it works in our bodies.
Patients seeking NAD+ IV therapy can consult with their doctor before starting it. It is not associated with a risk of toxicity, so they can be assured that it is safe.
As a good basis for reducing the number of NAD+ infusions, we recommend restoring the endorphin system.
- 2023 The potential of CD38 protein as a target for autoimmune diseases
- 2022 The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
- 2022 Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes
- 2022 A purine metabolic checkpoint that prevents autoimmunity and autoinflammation
- 2022 Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels
- 2022 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing
- 2022 NAD(+) metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity
- 2021 Nicotinamide adenine dinucleotide treatment alleviates the symptoms of experimental autoimmune encephalomyelitis by activating autophagy and inhibiting the NLRP3 inflammasome
- 2021 NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway