Charcot beschreef ALS voor het eerst tussen 1865 en 1874 als een ziekte die volwassenen treft en ontstaat door een onbekende, voortschrijdende aftakeling van het zenuwstelsel dat onze spieren aanstuurt. Dit leidt snel tot ernstige spierzwakte en afbraak van spieren. Er is geen genezing voor ALS en geen bewezen behandeling om het te voorkomen of terug te draaien. Er zijn wel twee medicijnen, riluzol en edaravone, specifiek goedgekeurd voor de behandeling van ALS, en veel andere worden nog getest of zijn in klinische proeven. Tot nu toe is er nog geen echte doorbraak in de behandeling van deze slopende ziekte. Ons begrip van ALS en hoe het ontstaat, wordt echter steeds beter. We weten dat schade door zuurstof (oxidatieve stress), veranderingen in de stofwisseling die afhankelijk zijn van NAD+ en de toestand van redox, en afwijkende werking en dynamiek van de mitochondriën, de energiefabriekjes in onze zenuwcellen, een belangrijke rol spelen. Daarom worden verschillende antioxidanten en stoffen die NAD+ aanmaken voorgesteld als mogelijke behandelingen voor ALS. Deze review bekijkt niet alleen het gebruik van deze stoffen op zichzelf, maar ook de mogelijkheid om ze te combineren, en zelfs als onderdeel van bredere, gecombineerde therapieën.
Artikel
NAD+ Precursors and Antioxidants for the Treatment of Amyotrophic Lateral Sclerosis
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